研究成果: |
课题组利用转基因小鼠为动物模型,结合脑立体定位注射,化学遗传方法,病毒环路示踪,行为学测试,高通量测序,细胞及分子生化等技术手段,揭示海马神经细胞在焦虑障碍及抑郁症发病过程中的作用和机制,同时致力于神经精神疾病与神经退行性疾病共病的机制研究。相关研究成果以通讯作者或第一作者(含共同)发表在Advanced Science, Biol. Psychiatry, PNAS, Cell Death & Disease, J. Neuroscience, Cell & Bioscience等主流学术期刊。主持国家自然科学基金青年项目,吉林省科技厅人才专项,吉林省自然科学基金面上项目,作为项目骨干参与科技创新2030-“脑科学与类脑研究”青年科学家项目。 主持科研项目: 1. 国家自然科学基金青年科学基金项目,项目编号:32200824,2023/01-2025/12,主持 2. 科技创新2030-“脑科学与类脑研究”青年科学家项目,项目编号:2022ZD0214300,2022/08-2027/07,项目骨干 3. 吉林省科技厅青年成长科技计划项目,项目编号:20220508067RC,2022/07-2024/06,主持 结题 4. 吉林省自然科学基金面上项目,项目编号:20250102276JC,2025/01-2027/12, 主持 代表性学术论文: 1. Zi-Jie Liu#, Jia-Rui Bi#, Zong-Yan Yu#, Meng Tian#, Zhi-Yue Chen, Ran Wei, Miao-Miao Wang, Hai-Wei Zha, Yu-Qing Zhang, Hong-Jing Wang, Bang-You Qiang, Shuang-Shuang Sun, Xiao-Juan Zhu*, Wen-Bing Chen*, Dong Sun*. (2025) Adenylyl cyclase 8 in dorsal CA1 neurons prevents depressive-like behaviors by maintaining neuronal excitability and glutamatergic neurotransmission through TIP39-PTH2R signaling. Advanced Science (中科院1区,IF: 14.1) 2. Qing-Lin Gao#, Hai-Wei Zha#, Zi-Jie Liu, Miao-Miao Wang, Yu-Qing Zhang, Jia-Rui Bi, Tian-Yang Wu, Zhen-Jiang Liu, Hui Wu and Dong Sun*. (2025) Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer’s disease progression. Cell and Bioscience (中科院2区,IF: 6.2) 3. Dong Sun, Lin Mei, and Wen-Cheng Xiong* (2023) Dorsal Dentate Gyrus, a Key Regulator for Mood and Psychiatric Disorders.Biological Psychiatry (中科院1区,IF: 10.6) 4. Dong Sun#,Zhi-Bing Tan#, Xiang-Dong Sun, Zhi-Peng Liu, Wen-Bing Chen, Leena Milibari, Xiao Ren, Ling-Ling Yao, Daehoon Lee, Chen Shen, Jin-Xiu Pan, Zhi-Hui Huang, Lin Mei, and Wen-Cheng Xiong*. (2021) Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response.PNAS (中科院1区,IF: 12.78) 5.Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wen-Bing Chen, Fu-Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen-Cheng Xiong*. (2021) Critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in BDNF, adult hippocampal neurogenesis, and anti-anxiety-like behaviors.Biological Psychiatry (中科院1区,IF: 12.81) 6.Dong Sun, Xiang-Dong Sun, Lu Zhao, Dae-Hoon Lee, Jin-Xia Hu, Fu-Lei Tang, Jin-Xiu Pan, Lin Mei, Xiao-Juan Zhu*, Wen-Cheng Xiong*. (2018) Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior.Cell Death & Disease (中科院2区,IF: 5.96) 7. Jin-Xiu Pan#,Dong Sun#,Daehoon Lee, Lei Xiong, Xiao Ren, Hao-han Guo, Ling-ling Yao, Yuyi Lu, Caroline Jung, Wen-Cheng Xiong*. (2021) Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.Communications Biology (中科院1区,IF: 6.55) 8. Xiang-Dong Sun#*, Wen-Bing Chen#,Dong Sun#,Jie Huang, Yuan-Quan Li, Jin-Xiu Pan, Ya-Nan Wang, Kai Zhao, Zhao-Qi Dong, Hong-Sheng Wang, Lei Xiong, Aiguo Xuan, Shen-Ting Zhao, Anilkumar Pillai, Wen-Cheng Xiong* and Lin Mei. (2018) Neogenin in Amygdala for Neuronal Activity and Information Processing.Journal of Neuroscience (中科院1区,IF: 6.07) |